Back to Search
Start Over
Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 1999 Dec; Vol. 100 (1-2), pp. 203-15. - Publication Year :
- 1999
-
Abstract
- Interleukin-1 (IL-1) has pleiotropic actions in the central nervous system. During the last decade, a growing corpus of evidence has indicated an important role of this cytokine in the development of brain damage following cerebral ischaemia. The expression of IL-1 in the brain is dramatically increased during the early and chronic stage of infarction. The most direct evidence that IL-1 contributes significantly to ischaemic injury is that (1) central administration of IL-1beta exacerbates brain damage, and (2) injection or over-expression of interleukin-1 receptor antagonist, and blockade of interleukin-1beta converting enzyme activity reduce, dramatically, infarction and improve behavioural deficit. The mechanisms underlying IL-1 actions in stroke are not definitively elucidated, and it seems likely that its effects are mediated through stimulation and inhibition of wide range of pathophysiological processes.
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 100
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 10695731
- Full Text :
- https://doi.org/10.1016/s0165-5728(99)00202-7