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Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 1999 Dec; Vol. 18 (12), pp. 866-70. - Publication Year :
- 1999
-
Abstract
- In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 microg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (-0.48+/-0.14 deltalog10 cfu/ml h) and slightly superior to ceftriaxone (-0.34+/-0.23 deltalog10 cfu/ml x h) and vancomycin (-0.39+/-0.19 deltalog10 cfu/ml x h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (-0.55+/-0.19 deltalog10 cfu/ml x h), only an insignificant gain was observed by the addition of vancomycin to meropenem (-0.55+/-0.28 deltalog10 cfu/ml x h).
- Subjects :
- Animals
Ceftriaxone cerebrospinal fluid
Ceftriaxone pharmacology
Ceftriaxone therapeutic use
Cephalosporins cerebrospinal fluid
Cephalosporins pharmacology
Cephalosporins therapeutic use
Colony Count, Microbial
Disease Models, Animal
Drug Therapy, Combination cerebrospinal fluid
Drug Therapy, Combination pharmacology
Meningitis, Pneumococcal microbiology
Meropenem
Microbial Sensitivity Tests
Penicillin Resistance
Rabbits
Thienamycins cerebrospinal fluid
Thienamycins pharmacology
Vancomycin cerebrospinal fluid
Vancomycin pharmacology
Drug Therapy, Combination therapeutic use
Meningitis, Pneumococcal drug therapy
Streptococcus pneumoniae drug effects
Thienamycins therapeutic use
Vancomycin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0934-9723
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 10691197
- Full Text :
- https://doi.org/10.1007/s100960050421