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Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression.
- Source :
-
Brain research. Molecular brain research [Brain Res Mol Brain Res] 2000 Feb 22; Vol. 75 (2), pp. 337-41. - Publication Year :
- 2000
-
Abstract
- We sought to determine whether the fragile X mental retardation gene fmr1 is regulated in long-term potentiation (LTP) and electroconvulsive shock (ECS). In situ hybridization of fmr1 mRNA in hippocampus of rats given LTP in vivo showed no change in fmr1 mRNA levels relative to control. However, ECS induced a selective increase in fmr1 mRNA expression in the dentate gyrus (DG) granule cell layer at 6 h post-ECS. The ECS paradigm may unmask relevant activity-dependent regulatory mechanisms that modulate fmr1 gene transcription in vivo.
- Subjects :
- Analysis of Variance
Animals
Dentate Gyrus chemistry
Electroshock
Fragile X Mental Retardation Protein
Immunohistochemistry
In Situ Hybridization
Nerve Tissue Proteins analysis
RNA, Messenger analysis
Rats
Rats, Sprague-Dawley
Dentate Gyrus metabolism
Gene Expression Regulation
Long-Term Potentiation genetics
Nerve Tissue Proteins genetics
RNA-Binding Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0169-328X
- Volume :
- 75
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research. Molecular brain research
- Publication Type :
- Academic Journal
- Accession number :
- 10686356
- Full Text :
- https://doi.org/10.1016/s0169-328x(99)00310-1