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Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2000 Feb 24; Vol. 268 (3), pp. 938-41. - Publication Year :
- 2000
-
Abstract
- Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been described. Interestingly, vMIP-II (but not vMIP-I) was found to be a potent antagonist of lymphotactin activity at GPR5/XCR1, extending the range of chemokine classes that this viral protein is known to inhibit to include the C class chemokine. In addition, we have extended previous analyses of GPR5/XCR1 expression and show that this receptor is expressed in leukocyte cells previously shown to be responsive to lymphotactin.<br /> (Copyright 2000 Academic Press.)
- Subjects :
- Animals
Base Sequence
Calcium metabolism
Cell Line
Cloning, Molecular
DNA Primers genetics
Gene Expression
Humans
Ligands
Lymphokines metabolism
Mice
Receptors, Cell Surface genetics
Recombinant Proteins genetics
Recombinant Proteins metabolism
Sialoglycoproteins metabolism
Tissue Distribution
Chemokines metabolism
Chemokines, C
Macrophage Inflammatory Proteins metabolism
Membrane Proteins
Receptors, Cell Surface metabolism
Receptors, G-Protein-Coupled
Viral Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 268
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 10679309
- Full Text :
- https://doi.org/10.1006/bbrc.2000.2235