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Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteries.

Authors :
Whelan DM
van der Giessen WJ
Krabbendam SC
van Vliet EA
Verdouw PD
Serruys PW
van Beusekom HM
Source :
Heart (British Cardiac Society) [Heart] 2000 Mar; Vol. 83 (3), pp. 338-45.
Publication Year :
2000

Abstract

Objective: To improve the biocompatibility of stents using a phosphorylcholine coated stent as a form of biomimicry.<br />Interventions: Implantation of phosphorylcholine coated (n = 20) and non-coated (n = 21) stents was performed in the coronary arteries of 25 pigs. The animals were killed after five days (n = 6), four weeks (n = 7), and 12 weeks (n = 8), and the vessels harvested for histology, scanning electron microscopy, and morphometry.<br />Main Outcome Measures: Stent performance was assessed by studying early endothelialization, neointima formation, and vessel wall reaction to the synthetic coating.<br />Results: Stent thrombosis did not occur in either group. Morphometry showed no significant differences between the two study groups at any time point. At five days both the coated and non-coated stents were equally well endothelialised (91% v 92%, respectively). At four and 12 weeks there was no difference in intimal thickness between the coated and non-coated stents. Up to 12 weeks postimplant the phosphorylcholine coating was still discernible in the stent strut voids, and did not appear to elicit an adverse inflammatory response.<br />Conclusion: In this animal model the phosphorylcholine coating showed excellent blood and tissue compatibility, unlike a number of other polymers tested in a similar setting. Given that the coating was present up to 12 weeks postimplant with no adverse tissue reaction, it may be a potential candidate polymer for local drug delivery.

Details

Language :
English
ISSN :
1355-6037
Volume :
83
Issue :
3
Database :
MEDLINE
Journal :
Heart (British Cardiac Society)
Publication Type :
Academic Journal
Accession number :
10677417
Full Text :
https://doi.org/10.1136/heart.83.3.338