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Postnatal profiles of myogenic regulatory factors and the receptors of TGF-beta 2, LIF and IGF-I in the gastrocnemius and rectus femoris muscles of dy mouse.
- Source :
-
Acta neuropathologica [Acta Neuropathol] 2000 Feb; Vol. 99 (2), pp. 169-76. - Publication Year :
- 2000
-
Abstract
- The dystrophin-deficient mdx mouse presents muscle fiber necrosis but active muscle regeneration, probably due to an extensive recruitment of myogenic regulatory factors (MRF), several growth factors and cytokines, and favorable interaction of satellite cells. In contrast, the laminin alpha 2 (merosin)-deficient dy mouse shows progressive muscle fiber necrosis and ineffective muscle regeneration. Using Western blot and immunohistochemical analyses, we investigated the adaptive changes in MRF, growth factors and cytokines and their receptors in the muscles of dy mice during postnatal growth. The relative volume of MyoD, myogenin and Myf-5 proteins was markedly lower in the gastrocnemius and rectus femoris muscles of dy mice. Transforming growth factor-beta 2, leukemia inhibitory factor (LIF) and basic fibroblast growth factor were not up-regulated in the muscles of dy mice. The levels of the LIF receptor and insulin-like growth factor-I receptor levels were markedly decreased in the muscles of dy mice during the entire postnatal period observed in this study. Therefore, unlike the situation in mdx mice, the milieu of regeneration following repetitive damage seems to be degraded in the muscles of dy mice.
- Subjects :
- Animals
Animals, Newborn
Leukemia Inhibitory Factor
Leukemia Inhibitory Factor Receptor alpha Subunit
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Muscle Fibers, Skeletal pathology
Muscle Fibers, Skeletal physiology
MyoD Protein analysis
Myogenic Regulatory Factor 5
Myogenin analysis
Necrosis
Receptor, IGF Type 1 analysis
Receptors, Cytokine analysis
Receptors, OSM-LIF
Regeneration
Aging physiology
DNA-Binding Proteins
Dystrophin genetics
Growth Inhibitors analysis
Insulin-Like Growth Factor I analysis
Interleukin-6
Lymphokines analysis
Muscle Development
Muscle Proteins analysis
Muscle, Skeletal growth & development
Muscle, Skeletal pathology
Receptors, Transforming Growth Factor beta analysis
Trans-Activators
Transforming Growth Factor beta analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6322
- Volume :
- 99
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 10672324
- Full Text :
- https://doi.org/10.1007/pl00007421