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Loss of expression of transforming growth factor beta type II receptor correlates with high tumour grade in human breast in-situ and invasive carcinomas.
- Source :
-
Histopathology [Histopathology] 2000 Feb; Vol. 36 (2), pp. 168-77. - Publication Year :
- 2000
-
Abstract
- Aims: Loss of transforming growth factor beta type II receptor (TGFbeta-RII) expression has been associated with resistance to TGFbeta-mediated inhibition of cell proliferation and tumour progression. We investigated whether the expression of TGFbeta-RII is related to the progression of human breast cancer and whether there is a correlation between TGFbeta-RII expression and phenotypic markers of biological aggressiveness.<br />Methods and Results: Immunohistochemical methods were used to detect TGFbeta-RII in archival breast samples including benign proliferative lesions, ductal carcinoma in situ (DCIS) and invasive mammary carcinomas (IMC). Neoplastic cells showed reduced expression of TGFbeta-RII in comparison to the normal breast tissue and benign lesions. There was a significant inverse correlation between loss of TGFbeta-RII expression and tumour grade within both DCIS (P = 0.004) and IMC (P = 0.001) groups. There was an inverse correlation between TGFbeta-RII expression and both mitotic count (P = 0.001) and clinical stage (P = 0.004). Oestrogen receptor (P = 0.07) and lymph node status (P = 0.10) were not significantly associated with TGFbeta-RII expression.<br />Conclusions: These data indicate that decreased expression of TGFbeta-RII may contribute to breast cancer progression and is related to a more aggressive phenotype in both in-situ and invasive carcinomas.
- Subjects :
- Adult
Aged
Aged, 80 and over
Breast chemistry
Breast pathology
Breast Neoplasms metabolism
Carcinoma in Situ metabolism
Carcinoma, Ductal, Breast metabolism
Carcinoma, Ductal, Breast pathology
Disease Progression
Female
Humans
Hyperplasia
Immunohistochemistry
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Protein Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta analysis
Breast Neoplasms pathology
Carcinoma in Situ pathology
Receptors, Transforming Growth Factor beta biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0309-0167
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 10672063
- Full Text :
- https://doi.org/10.1046/j.1365-2559.2000.00841.x