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Delimitation of the time of death by immunohistochemical detection of insulin in pancreatic beta-cells.

Authors :
Wehner F
Wehner HD
Schieffer MC
Subke J
Source :
Forensic science international [Forensic Sci Int] 1999 Nov 08; Vol. 105 (3), pp. 161-9.
Publication Year :
1999

Abstract

To improve the possibilities to delimitate the time of death after longer laytime, it was examined if this is possible by immunohistochemical insulin detection. The results show that in our examination material, the pancreatic beta-cells of up to 12-day-old corpses produce a positive immunoreaction towards insulin in all cases, whereas none of the corpses older than 30 days show such a reaction. This means that in case of a negative immunoreaction, the time of death can be assumed to lie more than 12 days before the autopsy. The fact that a negative immunoreaction occurs consistently after 30 days leads to the conclusion that when insulin has been stained in a specimen, the death of the respective person must lie a maximum of 29 days earlier, whereby these time-limits may change in considerably different surrounding conditions.

Details

Language :
English
ISSN :
0379-0738
Volume :
105
Issue :
3
Database :
MEDLINE
Journal :
Forensic science international
Publication Type :
Academic Journal
Accession number :
10643650
Full Text :
https://doi.org/10.1016/s0379-0738(99)00124-3