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Successful treatment of human herpesvirus-6 encephalitis after bone marrow transplantation.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 1999 Dec; Vol. 24 (11), pp. 1245-8. - Publication Year :
- 1999
-
Abstract
- We report two cases of human herpesvirus-6 (HHV-6)-associated encephalitis in patients after BMT. Both patients reported distinct neurological symptoms with disorientation, sleepiness and loss of short-term memory. Diagnosis was based on PCR analysis of the cerebrospinal fluid (CSF) positive for HHV-6 variant B-DNA. After institution of therapy with foscarnet in both cases, neurological symptoms improved and in one patient clearance of HHV-6-DNA from CSF was demonstrated. These cases show that HHV-6 infection has to be considered in patients with neurological symptoms following BMT and effective treatment of HHV-6 encephalitis is possible if instituted early.
- Subjects :
- Adult
Combined Modality Therapy
DNA, Viral cerebrospinal fluid
Encephalitis, Viral etiology
Encephalitis, Viral therapy
Female
Foscarnet administration & dosage
Herpesviridae Infections etiology
Herpesviridae Infections therapy
Humans
Male
Middle Aged
Polymerase Chain Reaction
Bone Marrow Transplantation
Encephalitis, Viral diagnosis
Herpesviridae Infections diagnosis
Herpesvirus 6, Human genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 24
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 10642816
- Full Text :
- https://doi.org/10.1038/sj.bmt.1702065