Back to Search
Start Over
Coagulation/fibrinolysis disorder in patients with severe preeclampsia.
- Source :
-
Seminars in thrombosis and hemostasis [Semin Thromb Hemost] 1999; Vol. 25 (5), pp. 451-4. - Publication Year :
- 1999
-
Abstract
- We investigated coagulation/fibrinolysis parameters in 50 patients with severe preeclampsia. The coagulation and clinical indices in patients with severe preeclampsia were 1.595 and 1.414, respectively. These indices show a strong correlation between the clinical status and coagulation/fibrinolysis abnormalities. Among patients with severe preeclampsia, a significant decrease in antithrombin (AT) (p = 0.002) and a significant increase in plasmin inhibitor complex (PIC) (p = 0.002), D-dimer (p < 0.05), and thrombin-antithrombin complex (TAT) (p = 0.001) were observed in cases terminated by cesarean section compared with those cases of vaginal delivery. There was no significant difference in platelet count (Plt), however, deltaPlt (the difference between platelet counts in early gestation and before delivery) was significantly larger (p < 0.05) in cases that ended in cesarean section. Furthermore, among cases terminated by cesarean section, a significant increase in PIC (p < 0.01) was observed when pregnancies were terminated because of maternal factors compared with those terminated because of fetal factors. These results suggest that (1) even in patients with severe preeclampsia, vaginal deliveries can be successful when they display a less hypercoagulable state; (2) a decrease in Plt during pregnancy may be a predictive marker for the termination of pregnancy; and (3) an excessive hypercoagulable state in patients with severe preeclampsia may be associated with the termination of pregnancy, especially when there is an aggravation of maternal factors.
- Subjects :
- Adult
Antifibrinolytic Agents blood
Antithrombin III analysis
Antithrombins analysis
Birth Weight
Blood Cell Count
Female
Fibrin Fibrinogen Degradation Products analysis
Gestational Age
Humans
Peptide Hydrolases analysis
Pre-Eclampsia physiopathology
Pregnancy
Severity of Illness Index
Thrombophilia physiopathology
alpha-2-Antiplasmin analysis
Fibrinolysis physiology
Pre-Eclampsia metabolism
Thrombophilia metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0094-6176
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Seminars in thrombosis and hemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 10625201
- Full Text :
- https://doi.org/10.1055/s-2007-994949