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Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 1999 Dec; Vol. 51 (6), pp. 757-63. - Publication Year :
- 1999
-
Abstract
- Objective: To investigate the suitability of intramuscular testosterone undecanoate (TU) injections for substitution therapy in hypogonadal men.<br />Study Design: Clinical, open-label, non-randomized trial of 13 hypogonadal men receiving 4 intramuscular injections of 1000 mg TU in 4-ml castor oil at 6-week intervals. General wellbeing, sexual parameters, clinical chemistry, hormone levels, prostate size and prostate-specific antigen (PSA) were evaluated over 24 weeks and compared with baseline values.<br />Results: Testosterone serum levels were never found below the lower limit of normal and only briefly after the 3rd and 4th injection above the upper limit of normal, while peak and trough values increased over the 24-week observation period. Oestradiol and dihydrotestosterone followed this pattern, not exceeding the normal limits. No serious side-effects were noted. Slight increases in body weight, haemoglobin, haematocrit, prostate volume and PSA, suppression of gonadotrophins as well as increased ejaculation frequency occurred as signs of adequate testosterone substitution.<br />Conclusion: Testosterone undecanoate is well tolerated by the patients. The injection intervals can be extended even beyond the 6-week periods chosen in the present study. Altogether, intramuscular testosterone undecanoate appears to be well suited for long-term substitution therapy in hypogonadism and hormonal male contraception.
- Subjects :
- Adult
Analysis of Variance
Body Weight drug effects
Dihydrotestosterone blood
Ejaculation drug effects
Estradiol blood
Humans
Hypogonadism blood
Injections, Intramuscular
Male
Middle Aged
Sex Hormone-Binding Globulin analysis
Testosterone administration & dosage
Testosterone blood
Testosterone therapeutic use
Hormone Replacement Therapy
Hypogonadism drug therapy
Testosterone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0664
- Volume :
- 51
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 10619981
- Full Text :
- https://doi.org/10.1046/j.1365-2265.1999.00881.x