Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.

Authors :: Cavalcanti SC
Xiang Y
Newton MG
Schinazi RF
Cheng YC
Chu CK
Source :: Nucleosides & nucleotides [Nucleosides Nucleotides] 1999 Oct; Vol. 18 (10), pp. 2233-52.
Publication Year :: 1999
Abstract: A series of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides has been synthesized as potential antiviral agents. The synthesized compounds were evaluated against HIV-1, HBV, HSV-1, and HSV-2. Among the synthesized analogues, only the cytosine derivative showed moderate antiviral activity against HIV and HBV.

Subjects :: Antiviral Agents chemistry
Antiviral Agents pharmacology
HIV-1 drug effects
Hepatitis B virus drug effects
Nucleosides chemistry
Nucleosides pharmacology
Simplexvirus drug effects
Stereoisomerism
Structure-Activity Relationship
Virus Replication drug effects
Antiviral Agents chemical synthesis
Nucleosides chemical synthesis

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