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The synthesis and biological activity of a highly selective adenosine A2a receptor agonist.
The synthesis and biological activity of a highly selective adenosine A2a receptor agonist.
- Source :
-
Nucleosides & nucleotides [Nucleosides Nucleotides] 1999 Oct; Vol. 18 (10), pp. 2175-91. - Publication Year :
- 1999
-
Abstract
- Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.
- Subjects :
- Adenosine chemical synthesis
Adenosine chemistry
Adenosine metabolism
Adenosine pharmacology
Animals
Blood Pressure drug effects
Dogs
Heart Rate drug effects
Hypertension physiopathology
In Vitro Techniques
Purine Nucleosides chemistry
Purine Nucleosides metabolism
Purine Nucleosides pharmacology
Rats
Receptor, Adenosine A2A
Adenosine analogs & derivatives
Purine Nucleosides chemical synthesis
Purinergic P1 Receptor Agonists
Subjects
Details
- Language :
- English
- ISSN :
- 0732-8311
- Volume :
- 18
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nucleosides & nucleotides
- Publication Type :
- Academic Journal
- Accession number :
- 10616724
- Full Text :
- https://doi.org/10.1080/07328319908044874