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Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Dec 06; Vol. 9 (23), pp. 3381-6. - Publication Year :
- 1999
-
Abstract
- The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP1-mediated uptake of the MRP1 substrate LTC4 into membrane vesicles prepared from MRP1-overexpressing cells.
- Subjects :
- Antineoplastic Agents pharmacology
Biological Transport
Cell Membrane metabolism
HL-60 Cells
HeLa Cells
Humans
Leukotriene C4 antagonists & inhibitors
Leukotriene C4 metabolism
Multidrug Resistance-Associated Proteins
ATP-Binding Cassette Transporters antagonists & inhibitors
Drug Resistance, Multiple genetics
Sulfonamides pharmacology
Thiophenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 9
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 10612603
- Full Text :
- https://doi.org/10.1016/s0960-894x(99)00610-1