Back to Search
Start Over
Dehydroepiandrosterone (DHEA) decreases open-field spontaneous activity of Zucker rats.
- Source :
-
Physiology & behavior [Physiol Behav] 1999 Nov; Vol. 67 (5), pp. 725-31. - Publication Year :
- 1999
-
Abstract
- The behavioral endpoint of open-field spontaneous activity was used to characterize further the central nervous system actions of dehydroepiandrosterone. DHEA, administered by intraperitoneal injection, causes a dose-dependent decrease in the spontaneous activity of lean and obese Zucker rats when exposed to a novel environment. The midpoint of DHEA's effect is around 50 mg/kg, a dose similar to that which reduces caloric intake of the rat by nearly 50%. d-Fenfluramine, a known anorectic agent, decreases spontaneous activity under the same conditions. Administration of either DHEA or d-fenfluramine leads to changes in serotonin or its metabolite, 5-hydroxyindole acetic acid, in select regions of the brain. These results emphasize that DHEA given peripherally can affect both the level of neurotransimitters and central nervous system function.
- Subjects :
- Animals
Appetite Depressants pharmacology
Brain Chemistry drug effects
Depression, Chemical
Diet
Energy Intake physiology
Feeding Behavior drug effects
Female
Fenfluramine pharmacology
Injections, Intraperitoneal
Male
Neurotransmitter Agents metabolism
Obesity genetics
Obesity psychology
Phenotype
Rats
Rats, Zucker
Sex Characteristics
Dehydroepiandrosterone pharmacology
Motor Activity drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0031-9384
- Volume :
- 67
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Physiology & behavior
- Publication Type :
- Academic Journal
- Accession number :
- 10604844
- Full Text :
- https://doi.org/10.1016/s0031-9384(99)00132-8