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Microsatellite instability and MLH1 and MSH2 germline defects are related to clinicopathological features in sporadic colorectal cancer.
- Source :
-
Oncology reports [Oncol Rep] 2000 Jan-Feb; Vol. 7 (1), pp. 39-43. - Publication Year :
- 2000
-
Abstract
- Clinical and pathological features were evaluated to predict tumor microsatellite instability (MSI) and germline mutations in MLH1 and MSH2 DNA mismatch repair genes in two patient groups with sporadic colorectal cancer (CRC): 38 young patients (age </=45 years) and 31 old patients (age >/=60 years). Nine (25.7%) young patients out of 35 and five (16%) old patients out of 31 exhibited MSI in their cancers. MSI+ cancers were related to proximal cancer and mucinous carcinoma independently of the age at cancer onset. Three (7.9%) out of 38 young patients had mutations in MLH1 and MSH2 genes that led to truncated protein products; they were all at age <35 years and showed MSI in their tumors, with mucinous histotype in two cases. In conclusion, histopathological and clinical features of CRC allow identification of cancers showing DNA microsatellite instability. MSI in CRC at very early onset (age <35 years) appears useful to predict germline MMR gene defects.
- Subjects :
- Adaptor Proteins, Signal Transducing
Adult
Base Pair Mismatch
Carrier Proteins
Colorectal Neoplasms pathology
Female
Humans
Male
Middle Aged
MutL Protein Homolog 1
MutS Homolog 2 Protein
Neoplasm Proteins genetics
Nuclear Proteins
Colorectal Neoplasms genetics
DNA Repair
DNA-Binding Proteins
Germ-Line Mutation
Microsatellite Repeats
Proto-Oncogene Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1021-335X
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 10601588
- Full Text :
- https://doi.org/10.3892/or.7.1.39