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Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region.
- Source :
-
Genomics [Genomics] 1999 Nov 15; Vol. 62 (1), pp. 113-8. - Publication Year :
- 1999
-
Abstract
- We report the identification of a new transcript homologous to the Drosophila staufen protein. This transcript, named STAU2 (HGMW-approved gene symbol and name), maps to the chromosome 8q13-q21 region. The full-length STAU2 cDNA is 4058 bp and contains an open reading frame of 479 amino acids. Analysis of the predicted protein product indicated the presence of three double-stranded RNA-binding domains. Best-fit analysis revealed a 48.5% similarity to the Drosophila protein and a 59.9% similarity to the recently described mammalian homolog hStau, indicating that at least two different transcripts with homologies to the fly protein are present in mammals.<br /> (Copyright 1999 Academic Press.)
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Binding Sites
DNA, Complementary genetics
Expressed Sequence Tags
Gene Duplication
Gene Expression
Genetic Diseases, Inborn genetics
Humans
Mammals genetics
Molecular Sequence Data
Open Reading Frames
Protein Structure, Tertiary
RNA metabolism
Sequence Alignment
Sequence Homology
Species Specificity
Chromosomes, Human, Pair 8 genetics
Drosophila Proteins
Drosophila melanogaster genetics
Genes
RNA-Binding Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0888-7543
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 10585778
- Full Text :
- https://doi.org/10.1006/geno.1999.6015