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Changes in plasma cystatin C after renal transplantation and acute rejection in adults.
- Source :
-
Clinical chemistry [Clin Chem] 1999 Dec; Vol. 45 (12), pp. 2243-9. - Publication Year :
- 1999
-
Abstract
- Background: Cystatin C has recently been proposed as an alternative marker of glomerular filtration rate. The diagnostic value of plasma cystatin C for the longitudinal assessment of kidney function after renal transplantation, however, has not been addressed.<br />Methods: Renal function was evaluated in 30 adults receiving renal transplants (46 +/- 9 years, mean +/- SD) and in 56 healthy controls (38 +/- 10 years) using cystatin C. Plasma cystatin C was determined daily starting the day of surgery and for 3 weeks after surgery by an immunonephelometric assay.<br />Results: Plasma concentration significantly decreased during the first week (-44% vs -29% for creatinine). Plasma cystatin C correlated with plasma creatinine (r = 0.741; P <0.0001) and the reciprocal of the creatinine clearance estimated by the Cockcroft-Gault formula (r = 0.882; P <0.001). In all three cases of acute renal impairment, the increase in plasma cystatin C values was more prominent than that of creatinine.<br />Conclusions: Plasma cystatin C is an alternative and accurate marker of allograft function in adult transplant patients. Increased sensitivity compared with creatinine for the detection of acute reduction in glomerular filtration rate allows in some cases a more rapid diagnosis of acute rejection or treatment nephrotoxicity.
- Subjects :
- Adult
Biomarkers blood
Creatinine blood
Cystatin C
Female
Follow-Up Studies
Graft Rejection physiopathology
Graft Rejection therapy
Humans
Immunosuppressive Agents therapeutic use
Kidney Failure, Chronic blood
Kidney Failure, Chronic surgery
Kidney Failure, Chronic therapy
Kidney Function Tests
Male
Middle Aged
Nephelometry and Turbidimetry economics
Nephelometry and Turbidimetry methods
Postoperative Period
Prospective Studies
Renal Dialysis
Steroids therapeutic use
Tacrolimus therapeutic use
Time Factors
Cystatins blood
Graft Rejection blood
Kidney Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9147
- Volume :
- 45
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 10585359