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Reversal in microfilarial density and T cell responses in human lymphatic filariasis.
- Source :
-
Parasite immunology [Parasite Immunol] 1999 Nov; Vol. 21 (11), pp. 565-71. - Publication Year :
- 1999
-
Abstract
- This study reports reversals in microfilarial density and the accompanying changes in cellular immune responses to filarial antigens of 39 individuals (11 microfilaria-positives, 22 microfilaria-negatives and six converters) living in an area endemic for brugian filariasis. Microfilarial counts decreased from April, the end of the rainy season to July, middle of the dry season (g.m. 88 mf/ml and 38 mf/ml, respectively; P = 0.001) and subsequently increased in November, the beginning of the rainy season (P = 0.088). Whereas the proliferative responses remained low throughout the study period in microfilaraemic individuals, in amicrofilaraemics these responses changed in the opposite direction to that of microfilarial densities. In three converters, proliferation changed in the opposite direction to the presence or absence of microfilariae. Cytokine analysis in the converters revealed that interferon-gamma was most affected by the shifts in microfilarial densities. In contrast, interleukin-4 responses showed little correlation with changes in parasite densities.
- Subjects :
- Adolescent
Adult
Animals
Cytokines metabolism
Female
Humans
Immunity, Cellular
Interferon-gamma metabolism
Interleukin-4 metabolism
Lymphocyte Activation
Male
Microfilariae isolation & purification
Brugia malayi growth & development
Elephantiasis, Filarial immunology
Elephantiasis, Filarial parasitology
Microfilariae growth & development
T-Lymphocyte Subsets immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0141-9838
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Parasite immunology
- Publication Type :
- Academic Journal
- Accession number :
- 10583857
- Full Text :
- https://doi.org/10.1046/j.1365-3024.1999.00253.x