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Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers.
- Source :
-
Cancer research [Cancer Res] 1999 Nov 15; Vol. 59 (22), pp. 5683-6. - Publication Year :
- 1999
-
Abstract
- Chromosome 8p21-22 is a frequent site of allelic deletions in many types of human tumors, including non-small cell lung cancer (NSCLC). Tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) is a cell-surface receptor involved in cell death signaling. The TRAIL-R2 gene recently has been mapped to chromosome 8p21-22. To explore the possibility that the TRAIL-R2 gene might be the relevant gene to the frequent deletion of 8p21-22 in NSCLC, we have analyzed the entire coding region and all splice sites of TRAIL-R2 for the detection of the somatic mutations in a series of 104 NSCLCs. Overall, 11 tumors (10.6%) were found to have TRAIL-R2 gene mutations in the death domain known to be involved in the transduction of an apoptotic signal. Our data indicate that somatic mutation of TRAIL-R2 may play a role in the pathogenesis of some NSCLCs and that the TRAIL-R2 gene is one of the genes relevant to the frequent loss of chromosome 8p21-22 in NSCLC.
- Subjects :
- Adenocarcinoma genetics
Amino Acid Sequence
Carcinoma, Squamous Cell genetics
Humans
Loss of Heterozygosity
Molecular Sequence Data
Mutation, Missense genetics
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Receptors, TNF-Related Apoptosis-Inducing Ligand
Carcinoma, Non-Small-Cell Lung genetics
Chromosomes, Human, Pair 8 genetics
Lung Neoplasms genetics
Mutation genetics
Receptors, Tumor Necrosis Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 59
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 10582684