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[The different vascular reactions of intact and ischemic brain to adrenergic exposures].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1999 Sep-Oct; Vol. 62 (5), pp. 11-4. - Publication Year :
- 1999
-
Abstract
- Electrical stimulation of the cervical sympathetic ganglion and norepinephrine increase the tonus of the cerebral vessels in intact animals. This points to the significant role of adrenergic mechanisms in regulation of blood circulation in the brain. Local ischemic affection of the brain removes the vasoconstrictor effects of stimulation of the cervical sympathetic ganglion and norepinephrine. Analysis by means of dihydroergotamine suggests that ischemia of the brain disturbs the property of alpha-adrenoceptors of the cerebral vessels to increase the tonus of the latter in response to adrenergic effects.
- Subjects :
- Adrenergic alpha-Agonists pharmacology
Animals
Cerebral Arteries drug effects
Cerebral Veins drug effects
Electric Stimulation instrumentation
Electric Stimulation methods
Laser-Doppler Flowmetry instrumentation
Laser-Doppler Flowmetry methods
Ligation
Norepinephrine pharmacology
Rats
Receptors, Adrenergic drug effects
Superior Cervical Ganglion physiology
Vascular Resistance drug effects
Vascular Resistance physiology
Brain Ischemia physiopathology
Cerebral Arteries physiology
Cerebral Veins physiology
Receptors, Adrenergic physiology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 62
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 10572743