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The herbal medicine Dai-Kenchu-Tou stimulates upper gut motility through cholinergic and 5-hydroxytryptamine 3 receptors in conscious dogs.
- Source :
-
Surgery [Surgery] 1999 Nov; Vol. 126 (5), pp. 918-24. - Publication Year :
- 1999
-
Abstract
- Background: The herbal medicine Dai-Kenchu-To, composed of zanthoxylum fruit, ginseng root, and dried ginger rhizome, is clinically effective for uncomplicated postoperative adhesive intestinal obstruction. We investigated the effect of Dai-Kenchu-To and each ingredient on upper gastrointestinal motility and its mechanism of action.<br />Methods: Five mongrel dogs were equipped with 4-strain gauge-force transducers on the gastric body, antrum, duodenum, and jejunum to measure contractile activity of the circular muscle. Dai-Kenchu-To (1.5 g) or the separate ingredients zanthoxylum fruit, ginseng root, or dried ginger rhizome (1.0 g each) were administered by bolus into the gastric lumen. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intragastric Dai-Kenchu-To-induced contractions was studied.<br />Results: Intragastric Dai-Kenchu-To induced phasic contractions in the antrum, duodenum, and jejunum. Zanthoxylum fruit elicited phasic contractions mainly in the duodenum and jejunum, whereas dried ginger rhizome induced phasic contractions in the antrum. Ginseng root had no effect. Phasic contractions induced by intragastric Dai-Kenchu-To were inhibited by atropine and hexamethonium at all sites, although ondansetron inhibited these contractions in the antrum and duodenum.<br />Conclusions: Intragastric Dai-Kenchu-To stimulates upper gastrointestinal motility through cholinergic and 5-hydroxytryptamine 3 receptors.
- Subjects :
- Animals
Atropine administration & dosage
Atropine pharmacology
Cholinergic Antagonists administration & dosage
Cholinergic Antagonists pharmacology
Dogs
Female
Zingiber officinale
Hexamethonium administration & dosage
Hexamethonium pharmacology
Intubation, Gastrointestinal
Male
Ondansetron administration & dosage
Ondansetron pharmacology
Panax
Plants, Medicinal
Protein Isoforms physiology
Serotonin Antagonists administration & dosage
Serotonin Antagonists pharmacology
Zanthoxylum
Zingiberaceae
Gastrointestinal Motility drug effects
Pharmaceutical Preparations
Plant Extracts pharmacology
Receptors, Cholinergic physiology
Receptors, Serotonin physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0039-6060
- Volume :
- 126
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 10568192