Aging and protein metabolism.

During aging, there are qualitative and quantitative modifications of proteins in various tissues. In muscle, myofibrillar and mitochondrial proteins are affected, resulting in a loss of strength and, to a lesser degree, endurance. Mechanisms of sarcopenia remain not well known and probably involve loss of motoneurons, muscle disuse and hormonal alterations. Partial prevention of muscle loss is possible by resistance training. In all tissues, and particularly in the brain, oxidative changes in proteins are likely to alter various functions of proteins.