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Altered surfactant protein B levels in transgenic mice do not affect clearance of bacteria from the lungs.
- Source :
-
Pediatric research [Pediatr Res] 1999 Nov; Vol. 46 (5), pp. 530-4. - Publication Year :
- 1999
-
Abstract
- To determine the role of surfactant protein B (SP-B) in bacterial clearance from the airways, three groups of mice expressing different levels of SP-B were studied: wild-type mice, hemizygous SP-B mice, and SP-B overexpressing transgenic mice. SP-B levels in overexpressing mice were increased 5-fold relative to hemizygous mice and 2- to 3-fold over wild-type littermates. Mice from each group were infected intratracheally with the common airway pathogens, group B streptococci or Pseudomonas aeruginosa. There was no significant difference in the number of recoverable viable bacteria at 6 h (group B streptococci and P. aeruginosa) and at 24 h (P. aeruginosa) among the three groups. Similarly, systemic dissemination of bacteria was not different among the three groups for both pathogens and at both time points. We conclude that SP-B levels in vivo do not influence clearance of bacteria from the lungs.
Details
- Language :
- English
- ISSN :
- 0031-3998
- Volume :
- 46
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 10541314
- Full Text :
- https://doi.org/10.1203/00006450-199911000-00007