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Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
- Source :
-
The Journal of dermatology [J Dermatol] 1999 Sep; Vol. 26 (9), pp. 577-86. - Publication Year :
- 1999
-
Abstract
- The "densities" of mast cells (MCs) in six kinds of vascular proliferation, pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma (MHE), measured per mm2 were studied using respective specimens prepared with tryptase stain and a personal computer. The average densities of MCs in pyogenic granuloma and MHE were 103.5 +/- 25.2/mm2 (n = 10) and 106.3 +/- 40.2/mm2 (n = 10) [mean +/- standard deviation (SD)]; that in normal skin was 6.85 +/- 4.9/mm2 (n = 20) (mean +/- SD). is a significant difference [t-test (p < 0.0001) and Wilcoxon-test (p < 0.01)]. The results in portwine stain (n = 4), cavernous hemangioma (n = 9), cherry angioma (n = 4), and Kaposi's sarcoma (n = 4) were 68.6 +/- 28.9/mm2, 105.7 +/- 56.9/mm2, 85.3 +/- 45.6/mm2, 82.2 +/- 28.4/mm2 (mean +/- SD), respectively, all of which were greater than that in normal skin by a simple comparison. The results of immunofluorescence microscopy were positive with basic fibroblast growth factor staining in the tissues of pyogenic granuloma, Kaposi's sarcoma and MHE. These facts may morphologically indicate a role of MCs in the angiogenesis of these vascular tumors.
- Subjects :
- Biopsy, Needle
Cell Division physiology
Cells, Cultured
Diagnosis, Differential
Endothelium, Vascular cytology
Endothelium, Vascular pathology
Endothelium, Vascular physiology
Female
Granuloma, Pyogenic diagnosis
Granuloma, Pyogenic pathology
Hemangioendothelioma diagnosis
Hemangioendothelioma pathology
Hemangioma diagnosis
Hemangioma pathology
Hemangioma, Cavernous diagnosis
Hemangioma, Cavernous pathology
Humans
Male
Microscopy, Fluorescence
Port-Wine Stain diagnosis
Reference Values
Sarcoma, Kaposi diagnosis
Sarcoma, Kaposi pathology
Sensitivity and Specificity
Skin Diseases diagnosis
Skin Neoplasms diagnosis
Mast Cells pathology
Port-Wine Stain pathology
Skin Diseases pathology
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0385-2407
- Volume :
- 26
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 10535252
- Full Text :
- https://doi.org/10.1111/j.1346-8138.1999.tb02052.x