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Effects of desipramine on autonomic input to the heart.
- Source :
-
Journal of the American Academy of Child and Adolescent Psychiatry [J Am Acad Child Adolesc Psychiatry] 1999 Sep; Vol. 38 (9), pp. 1186-92. - Publication Year :
- 1999
-
Abstract
- Objective: To examine the impact of age on the effects of desipramine (DMI) on autonomic input to the heart.<br />Method: Twenty-four-hour electrocardiograms were obtained from 42 subjects, aged 7 to 66 years, while off and on DMI. To obtain measures of autonomic input to the heart, heart rate variability was assessed via spectral analysis of RR interval variability.<br />Results: DMI treatment was associated with a significant increase in 24-hour mean heart rate and significant decreases in RR interval variability in all spectral bands, including in the high-frequency band, which provides a measure of parasympathetic input to the heart. RR interval variability was greater in younger individuals both off and on DMI.<br />Conclusions: DMI treatment was associated with a marked decline in RR interval variability, indicating that DMI affects autonomic input to the heart. Specifically, DMI reduced parasympathetic input, which, in theory, may increase vulnerability to arrhythmias. However, the magnitude of DMI's impact on RR interval variability did not vary with age.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Arrhythmias, Cardiac chemically induced
Arrhythmias, Cardiac physiopathology
Child
Female
Heart innervation
Humans
Male
Middle Aged
Parasympathetic Nervous System drug effects
Parasympathetic Nervous System physiology
Antidepressive Agents, Tricyclic pharmacology
Desipramine pharmacology
Heart Rate drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0890-8567
- Volume :
- 38
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the American Academy of Child and Adolescent Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 10504819
- Full Text :
- https://doi.org/10.1097/00004583-199909000-00025