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Evaluation of organic solvent ototoxicity by the upper limit of hearing.
- Source :
-
Archives of environmental health [Arch Environ Health] 1999 Sep-Oct; Vol. 54 (5), pp. 341-6. - Publication Year :
- 1999
-
Abstract
- To clarify the effects of organic solvents on hearing, we measured the upper limit of hearing in 93 male workers exposed to organic solvents in 7 factories that produced plastic buttons or baths. Medical examinations, environmental monitoring (i.e., concentration in breathing-zone air), and biological monitoring (i.e., concentration in urine) of the organic solvents were also done. Although the organic solvent concentrations in the environmental monitoring were lower than the occupational exposure limit, the upper limit of hearing was reduced in workers who were exposed for 5 y or more. This reduction was dose-dependent and was related to styrene concentrations in breathing-zone air and mandelic acid concentrations in urine. Even individuals who had normal medical examinations showed a reduced upper limit of hearing. The upper limit of hearing may serve as an early detection indicator of health effects in workers constantly exposed to styrene.
- Subjects :
- Acetone adverse effects
Adult
Age Distribution
Dose-Response Relationship, Drug
Environmental Monitoring
Epidemiological Monitoring
Hearing Loss, High-Frequency epidemiology
Humans
Industry
Japan epidemiology
Male
Methanol adverse effects
Middle Aged
Occupational Diseases epidemiology
Styrene adverse effects
Toluene adverse effects
Hearing Loss, High-Frequency chemically induced
Occupational Diseases chemically induced
Occupational Exposure adverse effects
Solvents adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9896
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of environmental health
- Publication Type :
- Academic Journal
- Accession number :
- 10501151
- Full Text :
- https://doi.org/10.1080/00039899909602498