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Evidence for polymorphism in glisentide.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 1999 Sep 20; Vol. 186 (2), pp. 199-204. - Publication Year :
- 1999
-
Abstract
- The polymorphism of glisentide has been investigated. Three polymorphs (I, II, III) have been prepared by recrystallization from different solvents and other polymorphic form (IV) was obtained by heating polymorph III at 100 degrees C. In addition, two 1:1 stoichiometric solvates containing carbon tetrachloride and dioxane have been crystallized and finally, an amorphous solid has been obtained. It has been observed that the polarity of the recrystallisation solvent and its ability to form hydrogen bonds have a great influence on the polymorphism of glisentide. The different solid forms of glisentide have been characterized using X-ray diffraction analysis, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), IR spectroscopy and optical microscopy. The recrystallization of polymorph I in melted form II and also the transition of form III-IV have been detected by DSC and X-ray diffraction analysis.
Details
- Language :
- English
- ISSN :
- 0378-5173
- Volume :
- 186
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 10486438
- Full Text :
- https://doi.org/10.1016/s0378-5173(99)00162-3