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Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide.

Authors :
Turecki G
Brière R
Dewar K
Antonetti T
Lesage AD
Séguin M
Chawky N
Vanier C
Alda M
Joober R
Benkelfat C
Rouleau GA
Source :
The American journal of psychiatry [Am J Psychiatry] 1999 Sep; Vol. 156 (9), pp. 1456-8.
Publication Year :
1999

Abstract

Objective: Postmortem studies have indicated that suicide victims have greater serotonin receptor 2A (5-HTR2A) binding in prefrontal brain regions. However, there remains some controversy regarding the biological specificity of these findings. The authors hypothesized that the variance observed in brain 5-HTR2A binding is genetically mediated, at least in part.<br />Method: Postmortem data from 56 subjects who had committed suicide and 126 normal comparison subjects were studied; brain tissue was available from 11 subjects who committed suicide and 11 comparison subjects. Homogenate binding assays were carried out with [3H]ketanserin. Variation at the 5-HTR2A gene (HTR2A) was investigated by means of two polymorphisms: T102C and A-1438G.<br />Results: 5-HTR2A binding was greater in the prefrontal cortex of the subjects who committed suicide. In addition, the findings suggest that HTR2A variation significantly affects 5-HTR2A binding. However, no interaction between suicidal behavior and this locus was observed.<br />Conclusions: These results confirm previous reports of greater 5-HTR2A binding in subjects who committed suicide; they also provide preliminary evidence suggesting that the number of 5-HTR2A receptors is genetically mediated.

Details

Language :
English
ISSN :
0002-953X
Volume :
156
Issue :
9
Database :
MEDLINE
Journal :
The American journal of psychiatry
Publication Type :
Academic Journal
Accession number :
10484964
Full Text :
https://doi.org/10.1176/ajp.156.9.1456