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Inappropriate antidiuretic hormone secretion after high-dose thiotepa.

Authors :
Sica S
Cicconi S
Sorà F
Chiusolo P
Piccirillo N
Laurenti L
La Barbera EO
Giordano G
Leone G
Source :
Bone marrow transplantation [Bone Marrow Transplant] 1999 Sep; Vol. 24 (5), pp. 571-2.
Publication Year :
1999

Abstract

High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.

Subjects

Subjects :
Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Brain Neoplasms drug therapy
Brain Neoplasms radiotherapy
Brain Neoplasms therapy
Combined Modality Therapy
Cranial Irradiation
Female
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma, Non-Hodgkin drug therapy
Lymphoma, Non-Hodgkin radiotherapy
Lymphoma, Non-Hodgkin therapy
Thiotepa administration & dosage
Inappropriate ADH Syndrome chemically induced
Thiotepa adverse effects
Transplantation Conditioning adverse effects

Details

Language :
English
ISSN :
0268-3369
Volume :
24
Issue :
5
Database :
MEDLINE
Journal :
Bone marrow transplantation
Publication Type :
Academic Journal
Accession number :
10482945
Full Text :
https://doi.org/10.1038/sj.bmt.1701922
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