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[Binding affinity to steroid hormone receptors and antiproliferative action on MCF-7 cells of coumarin derivatives and isoflavonoids].
- Source :
-
Annales pharmaceutiques francaises [Ann Pharm Fr] 1999 Jul; Vol. 57 (4), pp. 332-9. - Publication Year :
- 1999
-
Abstract
- The study of the relative binding affinity to steroïd hormonal receptors and of the antiproliferative action on MCF-7 cells of 3-arylcoumarines, 3-aryl-4-hydroxycoumarines, isoflavanones, isoflavan-4-ols and isoflavones, indicates a weak activity in the case of some representatives of coumarines.
- Subjects :
- Adrenalectomy
Animals
Breast Neoplasms
Cell Division drug effects
Coumarins pharmacokinetics
Female
Humans
Isoflavones pharmacokinetics
Kidney metabolism
Male
Rats
Receptors, Estrogen metabolism
Receptors, Glucocorticoid metabolism
Receptors, Mineralocorticoid metabolism
Recombinant Proteins metabolism
Structure-Activity Relationship
Thymus Gland metabolism
Tumor Cells, Cultured
Coumarins pharmacology
Isoflavones pharmacology
Receptors, Progesterone metabolism
Receptors, Steroid metabolism
Subjects
Details
- Language :
- French
- ISSN :
- 0003-4509
- Volume :
- 57
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annales pharmaceutiques francaises
- Publication Type :
- Academic Journal
- Accession number :
- 10472706