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Evaluation of growth hormone administration in patients with chronic heart failure secondary to coronary artery disease.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1999 Aug 15; Vol. 84 (4), pp. 430-3. - Publication Year :
- 1999
-
Abstract
- We have examined the effects of 6 months of treatment with growth hormone (GH) (0.02 U/kg/day) in 10 patients with chronic postischemic cardiac failure. Ten patients matched for age, body mass index, functional class, and ejection fraction served as a control group. In the GH group, 1 patient died and 2 were withdrawn from the study because of arrhythmia or worsening of heart failure. In the control group, 1 patient died and 1 patient was withdrawn from the study because of progressive heart failure. Among GH patients, those with an unfavorable outcome had a greater left ventricular end-diastolic diameter (79, 82, and 88 mm) on entry to the study than patients without adverse events (range 62 to 72 mm). At the end of the study, the seven GH patients reported a feeling of well-being and had a significant increase in their exercise test duration (462 +/- 121 vs 591 +/- 105 seconds, p <0.05). Low baseline insulin-like growth factor-I values were increased with GH treatment (189 +/- 52 vs 100 +/- 22 ng/ml, p <0.01). GH did not change left ventricular diameters or wall thickness. A trend toward decreased serum triglyceride levels and adipose body tissue associated with an increase in high-density lipoproteins was observed in the GH group. In conclusion, our present data support previous suggestions that GH treatment exerts some beneficial effects in patients with chronic, stabilized, moderately severe heart failure, but may have deleterious effects in patients with more severe heart failure.
- Subjects :
- Aged
Body Mass Index
Coronary Disease physiopathology
Drug Evaluation
Echocardiography, Doppler
Exercise Test
Follow-Up Studies
Growth Hormone administration & dosage
Heart Failure etiology
Heart Failure physiopathology
Heart Ventricles diagnostic imaging
Humans
Injections, Subcutaneous
Male
Middle Aged
Stroke Volume drug effects
Treatment Outcome
Coronary Disease complications
Growth Hormone therapeutic use
Heart Failure drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 84
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 10468082
- Full Text :
- https://doi.org/10.1016/s0002-9149(99)00328-8