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Late coronary occlusion after intracoronary brachytherapy.

Late coronary occlusion after intracoronary brachytherapy.

Authors :
Costa MA
Sabaté M
van der Giessen WJ
Kay IP
Cervinka P
Ligthart JM
Serrano P
Coen VL
Levendag PC
Serruys PW
Source :
Circulation [Circulation] 1999 Aug 24; Vol. 100 (8), pp. 789-92.
Publication Year :
1999

Abstract

Background: Intracoronary brachytherapy appears to be a promising technology to prevent restenosis. Presently, limited data are available regarding the late safety of this therapeutic modality. The aim of the study was to determine the incidence of late (>1 month) thrombosis after PTCA and radiotherapy.<br />Methods and Results: From April 1997 to March 1999, we successfully treated 108 patients with PTCA followed by intracoronary beta-radiation. Ninety-one patients have completed at least 2 months of clinical follow-up. Of these patients, 6.6% (6 patients) presented with sudden thrombotic events confirmed by angiography 2 to 15 months after intervention (2 balloon angioplasty and 4 stent). Some factors (overlapping stents, unhealed dissection) may have triggered the thrombosis process, but the timing of the event is extremely unusual. Therefore, the effect of radiation on delaying the healing process and maintaining a thrombogenic coronary surface is proposed as the most plausible mechanism to explain such late events.<br />Conclusions: Late and sudden thrombosis after PTCA followed by intracoronary radiotherapy is a new phenomenon in interventional cardiology.

Details

Language :
English
ISSN :
1524-4539
Volume :
100
Issue :
8
Database :
MEDLINE
Journal :
Circulation
Publication Type :
Academic Journal
Accession number :
10458712
Full Text :
https://doi.org/10.1161/01.cir.100.8.789