Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction.

Subjects

Subjects :

Acquired Immunodeficiency Syndrome enzymology
Animals
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System blood
Drug Interactions
Enzyme Induction drug effects
HIV Protease Inhibitors administration & dosage
Humans
Metabolic Clearance Rate drug effects
Microsomes, Liver drug effects
Microsomes, Liver enzymology
Oxidoreductases, N-Demethylating blood
Ritonavir administration & dosage
Acquired Immunodeficiency Syndrome drug therapy
Alprazolam pharmacokinetics
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 Enzyme Inhibitors
HIV Protease Inhibitors adverse effects
Hypnotics and Sedatives pharmacokinetics
Oxidoreductases, N-Demethylating antagonists & inhibitors
Ritonavir adverse effects
Triazolam pharmacokinetics

Details

Language :

English

ISSN :

0271-0749

Volume :

19

Issue :

4

Database :

MEDLINE

Journal :

Journal of clinical psychopharmacology

Publication Type :

Review

Accession number :

10440454

Full Text :

https://doi.org/10.1097/00004714-199908000-00001