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HTLV-I/II seroindeterminate Western blot reactivity in a cohort of patients with neurological disease.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1999 Sep; Vol. 180 (3), pp. 685-94. - Publication Year :
- 1999
-
Abstract
- The human T-cell lymphotropic virus type I (HTLV-I) is associated with a chronic, progressive neurological disease known as HTLV-I-associated myelopathy/tropical spastic paraparesis. Screening for HTLV-I involves the detection of virus-specific serum antibodies by EIA and confirmation by Western blot. HTLV-I/II seroindeterminate Western blot patterns have been described worldwide. However, the significance of this blot pattern is unclear. We identified 8 patients with neurological disease and an HTLV-I/II seroindeterminate Western blot pattern, none of whom demonstrated increased spontaneous proliferation and HTLV-I-specific cytotoxic T lymphocyte activity. However, HTLV-I tax sequence was amplified from the peripheral blood lymphocytes of 4 of them. These data suggest that patients with chronic progressive neurological disease and HTLV-I/II Western blot seroindeterminate reactivity may harbor either defective HTLV-I, novel retrovirus with partial homology to HTLV-I, or HTLV-I in low copy number.
- Subjects :
- Adult
Blotting, Western methods
Cohort Studies
Female
Genes, Viral
HTLV-I Antibodies blood
HTLV-II Antibodies blood
HTLV-II Infections immunology
HTLV-II Infections physiopathology
Humans
Male
Middle Aged
Nervous System Diseases immunology
Paraparesis, Tropical Spastic immunology
Paraparesis, Tropical Spastic physiopathology
Polymerase Chain Reaction
HTLV-II Infections virology
Human T-lymphotropic virus 1 isolation & purification
Human T-lymphotropic virus 2 isolation & purification
Nervous System Diseases virology
Paraparesis, Tropical Spastic virology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 180
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 10438355
- Full Text :
- https://doi.org/10.1086/314923