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New classes of fluorinated L-nucleosides; synthesis and antiviral activity.
- Source :
-
Nucleosides & nucleotides [Nucleosides Nucleotides] 1999 Apr-May; Vol. 18 (4-5), pp. 537-40. - Publication Year :
- 1999
-
Abstract
- The synthesis of 3'-fluorinated apionucleosides 7 and 2'-fluoro-2',3'-unsaturated L-nucleosides 8 via common synthon, 2-fluoro-butenolide 2, has been described. Among the newly synthesized nucleosides, L-2'-F-d4C, L-2'-F-d4FC and L-2'-F-d4A exhibit significant anti-HIV and anti-HBV activities.
- Subjects :
- Antiviral Agents chemistry
Crystallography, X-Ray
HIV-1 drug effects
Hepatitis B virus drug effects
Microbial Sensitivity Tests
Molecular Structure
Nucleosides chemistry
Antiviral Agents chemical synthesis
Antiviral Agents pharmacology
Fluorine chemistry
Nucleosides chemical synthesis
Nucleosides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0732-8311
- Volume :
- 18
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- Nucleosides & nucleotides
- Publication Type :
- Academic Journal
- Accession number :
- 10432644
- Full Text :
- https://doi.org/10.1080/15257779908041489