Back to Search
Start Over
Serum mucin antigen (CASA) as a marker of amiodarone-induced pulmonary toxicity.
- Source :
-
Disease markers [Dis Markers] 1998 Nov; Vol. 14 (3), pp. 169-75. - Publication Year :
- 1998
-
Abstract
- Amiodarone is used to treat life-threatening cardiac arrhythmias. Amiodarone-induced pulmonary toxicity (APT) can be difficult to diagnose. APT may result in increased mucus production and mucin expression. Thus, serum mucin-1 was evaluated as a marker for amiodarone-induced pulmonary toxicity. Concentrations of mucin-1 in peripheral blood were determined using cancer-associated serum antigen (CASA) assay in patients taking amiodarone. Eight of ten patients who developed major amiodarone toxicity had high serum CASA levels. Patients with toxicity had a significantly higher mean rank CASA concentration compared with those without major toxicity. CASA shows potential as a marker for amiodarone-induced toxicity, particularly pulmonary toxicity.
Details
- Language :
- English
- ISSN :
- 0278-0240
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Disease markers
- Publication Type :
- Academic Journal
- Accession number :
- 10427477
- Full Text :
- https://doi.org/10.1155/1998/496028