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A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 1999 Jun 30; Vol. 878, pp. 290-310. - Publication Year :
- 1999
-
Abstract
- Estrogen deficiency in the postmenopausal (PM) female is the major cause of osteoporosis and may contribute to increased periodontal disease, including alveolar bone loss, seen in these women. In the current study, an animal model of PM osteoporosis, the OVX adult female rat, was studied to determine: (i) the relationship between periodontal breakdown and skeletal bone loss, and (ii) the effect of CMT-8 on gingival collagenase and bone loss. OVX rats were daily gavaged with CMT-8 (1, 2, or 5 mg/rat) for 28 or 90 days; non-OVX rats and those gavaged with vehicle alone served as controls. Elevated collagenase activity, assessed using [3H-methyl] collagen as substrate in the presence or absence of APMA, was seen in the gingiva of the OVX rats, and CMT-8 therapy suppressed this effect. Western blot revealed a similar pattern for MMP-8 and MMP-13 concentrations. The changes in the gingival collagenase activity paralleled changes in periodontal bone loss, which, in turn, reflected trabecular bone density changes. Preliminary studies on PM humans administered sub-antimicrobial tetracycline as a matrix metalloproteinase inhibitor are under way.
- Subjects :
- Animals
Collagenases metabolism
Extracellular Matrix enzymology
Female
Gelatinases metabolism
Humans
Matrix Metalloproteinase Inhibitors
Ovariectomy
Periodontium pathology
Protease Inhibitors pharmacology
Rats
Tetracyclines pharmacology
Alveolar Bone Loss prevention & control
Gingiva enzymology
Metalloendopeptidases antagonists & inhibitors
Osteoporosis prevention & control
Periodontium drug effects
Protease Inhibitors therapeutic use
Tetracyclines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0077-8923
- Volume :
- 878
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 10415737
- Full Text :
- https://doi.org/10.1111/j.1749-6632.1999.tb07691.x