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Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues.

Authors :
Yang L
Morriello G
Leung K
Jacks T
Cheng K
Schleim KD
Smith R
Patchett AA
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Jul 05; Vol. 9 (13), pp. 1761-6.
Publication Year :
1999

Abstract

Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.

Details

Language :
English
ISSN :
0960-894X
Volume :
9
Issue :
13
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
10406638
Full Text :
https://doi.org/10.1016/s0960-894x(99)00286-3