Multifocal intraocular malignant melanoma: report of two cases and review of the literature.

Purpose: To describe two eyes from two patients with multifocal primary intraocular melanoma.
Design: Two case reports.
Methods: The history and histologic findings in the enucleated eyes of two patients with multifocal intraocular melanoma are described in comparison to previously reported cases.
Main Outcome Measures: Pathologic examination of enucleated eyes.
Results: One of the two eyes contained mixed cell type melanomas, and one eye contained spindle cell type melanomas. Examination of serial sections showed no continuity between the intraocular melanomas. There were no associated ocular or systemic conditions with the multifocal intraocular melanomas.
Conclusions: Multifocal primary intraocular melanoma is rare. There is no known predisposing factor to this condition.