Back to Search
Start Over
Calcium release from InsP3-sensitive internal stores initiates action potential in Chara.
- Source :
-
FEBS letters [FEBS Lett] 1999 Jun 18; Vol. 453 (1-2), pp. 72-6. - Publication Year :
- 1999
-
Abstract
- Neomycin and U73122 are known to suppress inositol 1,4,5-trisphosphate (InsP3) production by inhibition of phospholipase C. We studied the effects of these inhibitors on the excitatory currents, Iex, in Chara corallina under voltage-clamp conditions. Computer simulations of the experimental effects by a minimum model for the excitatory reaction pathway allow the assignment of the inhibitory effects to one specific reaction step, i.e. the release of Ca2+ from InsP3-sensitive internal stores. In contrast, the inhibitory effect of La3+ on Iex suggests inactivation of Cl- channels. Furthermore, ryanodine-sensitive Ca2+ stores seem to be irrelevant for electrical excitation in Chara.
- Subjects :
- Calcium Channel Blockers pharmacology
Electric Conductivity
Estrenes pharmacology
Inositol 1,4,5-Trisphosphate pharmacology
Lanthanum pharmacology
Models, Biological
Neomycin pharmacology
Pyrrolidinones pharmacology
Ryanodine pharmacology
Type C Phospholipases antagonists & inhibitors
Calcium metabolism
Chlorophyta physiology
Inositol 1,4,5-Trisphosphate metabolism
Membrane Potentials
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 453
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 10403378
- Full Text :
- https://doi.org/10.1016/s0014-5793(99)00600-6