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Abciximab readministration: A single-operator community-hospital experience.
- Source :
-
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 1999 Jul; Vol. 47 (3), pp. 294-6; discussion 297. - Publication Year :
- 1999
-
Abstract
- Abciximab, a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor, reduces ischemic complications of coronary interventions after first administration. In this study, We sought to determine whether readministration of abciximab is associated with equal efficacy and safety. We retrospectively reviewed the charts of 35 patients who received two doses of abciximab at separate intervals. We monitored patients clinically for recurrent ischemia, bleeding complications, and thrombocytopenia. We measured hemoglobin and platelet counts before and after readministration of abciximab. There was no cardiac-related death, myocardial infarction, or recurrent ischemia. No obvious bleeding occurred in any of the 35 patients, although 1 patient had a drop of hemoglobin >3 gm/dl. We observed one episode of severe thrombocytopenia without any complication, and this patient improved without requiring platelet transfusion. There was no profound thrombocytopenia. We conclude that readministration of abciximab was well tolerated without any evidence of altered efficacy or safety. Cathet. Cardiovasc. Intervent. 47:294-296, 1999.<br /> (Copyright 1999 Wiley-Liss, Inc.)
- Subjects :
- Abciximab
Angina Pectoris therapy
Antibodies, Monoclonal administration & dosage
Female
Humans
Immunoglobulin Fab Fragments administration & dosage
Male
Middle Aged
Platelet Aggregation Inhibitors administration & dosage
Retreatment
Retrospective Studies
Thrombocytopenia etiology
Time Factors
Angioplasty, Balloon, Coronary
Antibodies, Monoclonal therapeutic use
Immunoglobulin Fab Fragments therapeutic use
Platelet Aggregation Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1946
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
- Publication Type :
- Academic Journal
- Accession number :
- 10402280
- Full Text :
- https://doi.org/10.1002/(sici)1522-726x(199907)47:3<294::aid-ccd7>3.0.co;2-q