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CD4 lymphocyte count as a predictor of the duration of highly active antiretroviral therapy-induced suppression of human immunodeficiency virus load.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1999 Aug; Vol. 180 (2), pp. 530-3. - Publication Year :
- 1999
-
Abstract
- The association between CD4 cell count and duration of virus load suppression was investigated in 558 patients in the Frankfurt HIV Clinic Cohort who had begun highly active antiretroviral therapy and who had virus load declines to </=500 copies/mL. The Kaplan-Meier method estimated viral rebound in 42.5% of patients by 24 weeks and in 64.3% by 84 weeks. Risk of viral rebound was independently associated with baseline and changes from baseline CD4 cell count. The achieved CD4 cell count was the most important factor for prediction of viral rebound (relative hazard, 5.4 for an updated CD4 cell count of <20 vs. >500 copies/mL; P=.0001). Baseline virus load was not associated with virus load rebound. Lower baseline CD4 cell counts were associated with increased risk of viral rebound; however, this risk was significantly reduced in persons with low baseline CD4 cell counts who experienced substantial increases in CD4 cell counts during follow-up.
- Subjects :
- Adult
Anti-HIV Agents pharmacology
Cohort Studies
Drug Therapy, Combination
HIV Infections immunology
HIV Infections virology
HIV-1 drug effects
Humans
Predictive Value of Tests
RNA, Viral blood
Viral Load
Viremia drug therapy
Viremia immunology
Viremia virology
Anti-HIV Agents therapeutic use
CD4 Lymphocyte Count
HIV Infections drug therapy
HIV-1 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 180
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 10395876
- Full Text :
- https://doi.org/10.1086/314890