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Biochemical basis of oligofructose-induced hypolipidemia in animal models.
- Source :
-
The Journal of nutrition [J Nutr] 1999 Jul; Vol. 129 (7 Suppl), pp. 1467S-70S. - Publication Year :
- 1999
-
Abstract
- Oligofructose (OFS), a mixture of nondigestible/fermentable fructooligosaccharides, decreases serum triacylglycerol (TAG) when it is included in the standard, fiber-free or high fat diet of rats. This paper summarizes in vivo and in vitro data to establish a biochemical mechanism underlying the hypolipidemic effect of OFS. When OFS is added to the standard (carbohydrate-rich) diet of rats at the dose of 10 g/100 g, a TAG-lowering action occurs as a consequence of a reduction of de novo liver fatty acid synthesis. The depression in the activity of all lipogenic enzymes and fatty acid synthase mRNA suggests that OFS modifies the gene expression of lipogenic enzymes. Through its modulation of de novo lipogenesis, OFS can protect against liver lipid accumulation induced by providing 10% fructose-enriched water for 48 h. OFS also significantly decreases serum insulin and glucose, which are both known to participate in the nutritional regulation of lipogenesis. It also increases the intestinal production of incretins, namely, glucose-dependent insulinotropic peptide and glucagon-like peptide 1. This latter phenomenon results mainly from promotion of intestinal tissue proliferation by oligofructose fermentation end-products. Collectively, a link likely exists between the modulation of hormone and incretin production by OFS, and its antilipogenic effect.
- Subjects :
- Animals
Blood Glucose drug effects
Gene Expression Regulation, Enzymologic drug effects
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Insulin blood
Lipoproteins biosynthesis
Liver drug effects
Liver metabolism
Male
Neurotransmitter Agents biosynthesis
Oligosaccharides administration & dosage
Peptide Fragments biosynthesis
Rats
Rats, Wistar
Dietary Fiber pharmacology
Fatty Acids metabolism
Lipoproteins blood
Oligosaccharides pharmacology
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3166
- Volume :
- 129
- Issue :
- 7 Suppl
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 10395622
- Full Text :
- https://doi.org/10.1093/jn/129.7.1467S