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Improved glycemic control reduces the impact of weight gain on cardiovascular risk factors in type 1 diabetes. The Epidemiology of Diabetes Complications Study.
- Source :
-
Diabetes care [Diabetes Care] 1999 Jul; Vol. 22 (7), pp. 1084-91. - Publication Year :
- 1999
-
Abstract
- Objective: To assess the prevalence and incidence of being overweight in type 1 diabetes, to identify factors associated with weight gain and improved glycemic control, and to examine relationships among weight gain, glycemic control, and cardiovascular risk factors.<br />Research Design and Methods: The prevalence and incidence of being overweight in the Pittsburgh Epidemiology of Diabetes Complications (EDC) cohort (n = 441) were compared with the general population (National Health and Nutrition Examination Survey [NHANES]). Factors associated with weight gain and improved glycemic control were identified, and relationships among weight gain, glycemic control, and cardiovascular risk factors were examined over a 6.9 +/- 2.2-year period.<br />Results: At baseline, the prevalence of being overweight (BMI > 27.8 kg/m2 for men and > 27.3 kg/m2 for women) was 10.4 and 11.4%, respectively, and was lower than the age- and sex-specific estimate for the general population (P < 0.05). The incidence of being overweight was comparable in men (12.6%) and women (11.8%) and did not differ from the general population (P = 0.98). Weight gain correlated with improvements in HbA1c (r = -0.21, P < 0.001). Patients with the highest baseline HbA1c levels gained the most weight and had the greatest improvement in glycemic control. A lower baseline BMI was also associated with a greater improvement in glycemic control. Weight gain favorably influenced the lipid profile in the setting of improved glycemic control, but adversely influenced the lipid profile in the absence of improved glycemic control. Weight change was directly associated with blood pressure change, but the incidence of hypertension was more strongly influenced by the development of nephropathy.<br />Conclusions: The prevalence of being overweight in type 1 diabetes remains lower than that in the general population. Moderate weight gain did not adversely affect the cardiovascular risk profile in the setting of improved glycemic control.
- Subjects :
- Adult
Age Factors
Blood Pressure
Body Constitution
Body Mass Index
Cholesterol, HDL blood
Cholesterol, LDL blood
Cohort Studies
Diabetes Mellitus blood
Diabetes Mellitus physiopathology
Diabetes Mellitus, Type 1 blood
Female
Follow-Up Studies
Humans
Incidence
Lipids blood
Male
Pennsylvania
Risk Factors
Sex Factors
Time Factors
Blood Glucose metabolism
Cardiovascular Diseases epidemiology
Diabetes Mellitus epidemiology
Diabetes Mellitus, Type 1 physiopathology
Diabetic Angiopathies epidemiology
Obesity
Weight Gain
Subjects
Details
- Language :
- English
- ISSN :
- 0149-5992
- Volume :
- 22
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 10388972
- Full Text :
- https://doi.org/10.2337/diacare.22.7.1084