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Long-term results of preoperative intra-arterial doxorubicin combined with neoadjuvant radiotherapy, followed by extensive surgical resection for locally advanced soft tissue sarcomas of the extremities.

Authors :
Nijhuis PH
Pras E
Sleijfer DT
Molenaar WM
Koops HS
Hoekstra HJ
Source :
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 1999 Apr; Vol. 51 (1), pp. 15-9.
Publication Year :
1999

Abstract

Background and Purpose: In the 1980s a combined modality therapy of intraarterial doxorubicin, neoadjuvant radiotherapy and surgery was initiated at the Groningen University Hospital as a limb-saving treatment for locally advanced, primarily irresectable high-grade soft tissue sarcomas (STS) of the extremities. This study presents the short- and long-term results.<br />Patients and Methods: Between 1983 and 1987, 11 patients were treated with intraarterial doxorubicin, preoperative radiotherapy (10 x 3.5 Gy) and surgical resection. Non-radical resections received additional postoperative radiotherapy of 20-30 Gy.<br />Results: The limb-salvage rate was 91%, without local recurrences during a median follow-up of 84 months. Six patients died (55%); five from metastatic disease (45%). There were five long-term survivors with a median follow-up of 10 years. Three patients (60%) suffered serious late complications, resulting in disabilitating limb function.<br />Conclusion: Although this approach is feasible as a limb-saving treatment for these unfavorable STS, long-term morbidity is high.

Details

Language :
English
ISSN :
0167-8140
Volume :
51
Issue :
1
Database :
MEDLINE
Journal :
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Publication Type :
Academic Journal
Accession number :
10386712
Full Text :
https://doi.org/10.1016/s0167-8140(99)00003-1