Back to Search Start Over

Outcome of liver transplantation in hepatitis C virus-infected patients who received hepatitis C virus-infected grafts.

Authors :
Vargas HE
Laskus T
Wang LF
Lee R
Radkowski M
Dodson F
Fung JJ
Rakela J
Source :
Gastroenterology [Gastroenterology] 1999 Jul; Vol. 117 (1), pp. 149-53.
Publication Year :
1999

Abstract

Background & Aims: The present organ shortage has brought into question the suitability of hepatitis C virus (HCV)-positive grafts. This study reviewed the outcome of such transplantations in our institution.<br />Methods: Twenty-three HCV-positive patients who underwent orthotopic liver transplantation (OLT) for end-stage liver disease with HCV-positive grafts in 1992-1995 were studied. Only patients who survived more than 30 days were included in the analysis. Control group included 169 patients who underwent transplantation for HCV-related cirrhosis and received HCV-negative organs.<br />Results: Patients who received HCV-infected organs had a cumulative survival rate of 89% and 72% at 1 and 5 years, respectively, vs. 88% and 73% for the control group (NS). There was no difference in graft survival, incidence of cirrhosis, mean hepatitis activity index score, fibrosis, or mean activity of serum transaminases. There was a trend toward lower incidence of recurrent hepatitis C in the study group compared with control (21% vs. 23% at 1 year and 47% vs. 64% at 5 years; NS). Patients in whom the donor strain became predominant after transplantation had significantly longer disease-free survival than patients who retained their own HCV strain (P < 0.003).<br />Conclusions: HCV-infected livers transplanted into HCV-infected recipients do not appear to convey a worse outcome in the initial years after OLT than HCV-negative grafts.

Details

Language :
English
ISSN :
0016-5085
Volume :
117
Issue :
1
Database :
MEDLINE
Journal :
Gastroenterology
Publication Type :
Academic Journal
Accession number :
10381921
Full Text :
https://doi.org/10.1016/s0016-5085(99)70561-5