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Possible involvement of arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 genes in the development of endometriosis.
- Source :
-
Molecular human reproduction [Mol Hum Reprod] 1999 Jul; Vol. 5 (7), pp. 636-41. - Publication Year :
- 1999
-
Abstract
- Wide inter-individual variation of expression of compound metabolic enzymes is determined by polymorphism and may predispose the development of diseases provoked by environmental factors. The combined analysis of phase II detoxification system genes: arylamine N-acetyltransferase 2 (NAT2), and glutathione S-transferases (GST) M1 and T1 was carried out in patients with minimal/mild (group I; n = 36) and moderate/severe endometriosis (group II; n = 29) and controls (n = 72) of French origin, using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The results show a significant difference between patients and controls with regard to NAT2 gene polymorphism (P < 0.05). This is mainly due to the high percentage of slow acetylator genotypes (SA) in patients compared with controls (60.0 versus 38.9%; P < 0.02) with a distinct preponderance in subjects with minimal/mild endometriosis (69.4%, P < 0.005) where there is a significantly elevated frequency of slow allele S1 (NAT2*5) (P = 0.05). Significantly increased proportions of GSTM1-deficient genotypes were found in both groups of patients, in comparison with the controls (75.0 and 79.3% versus 45.8%; P < 0. 0001). A preponderance of GSTT1-negative subjects among patients was also detected, but did not appear significant. We suggest the involvement of both NAT2 and GSTM1 detoxification system genes in the pathogenesis of endometriosis and the possible impact of NAT2 gene polymorphism in the development of different forms of this disease.
- Subjects :
- DNA blood
DNA Primers
Endometriosis physiopathology
Endometrium pathology
Female
France
Humans
Infertility, Female etiology
Isoenzymes genetics
Pain
Polymerase Chain Reaction
Reference Values
Arylamine N-Acetyltransferase genetics
Endometriosis enzymology
Endometriosis genetics
Glutathione Transferase genetics
Polymorphism, Restriction Fragment Length
Subjects
Details
- Language :
- English
- ISSN :
- 1360-9947
- Volume :
- 5
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Molecular human reproduction
- Publication Type :
- Academic Journal
- Accession number :
- 10381818
- Full Text :
- https://doi.org/10.1093/molehr/5.7.636