Back to Search
Start Over
Some membrane property changes following axotomy in A delta-type DRG cells are related to cold allodynia in rat.
- Source :
-
Neuroreport [Neuroreport] 1999 May 14; Vol. 10 (7), pp. 1493-9. - Publication Year :
- 1999
-
Abstract
- Numerous studies have suggested that changes in electrophysiological properties of primary sensory neurons after axonal injury contribute to the generation of neuropathic pain. Presently, however, it is unclear which of the changes is important. To address this issue, we performed behavioral and electrophysiological experiments in a double-blind fashion; we made intracellular recordings in the S1 dorsal root ganglia excised from rats exhibiting cold allodynia behavior after chronic S1 spinal nerve transaction (allodynia-positive group) and from rats lacking such behavior after the same nerve injury (allodynia-negative group) or sham injury (sham group). In this study, we sought which of the membrane property changes produced by the spinal nerve injury in each of C-, Adelta- and Aalpha/beta-cell populations was unique to the allodynia-positive group. Analyses of our data revealed that only some changes in Adelta-cells (e.g. the decrease in resting membrane potential and in the threshold of central process) were more pronounced in or unique to the allodynia-positive group. We concluded that certain membrane property changes in the somata and dorsal root axons of Adelta-cells might be important in the generation of cold allodynia.
- Subjects :
- Action Potentials physiology
Animals
Axotomy
Behavior, Animal physiology
Evoked Potentials physiology
Ganglia, Spinal pathology
Male
Nerve Fibers pathology
Neuralgia etiology
Neuralgia pathology
Rats
Rats, Sprague-Dawley
Cold Temperature
Ganglia, Spinal physiopathology
Nerve Fibers physiology
Neuralgia physiopathology
Peripheral Nerve Injuries
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 10
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 10380969
- Full Text :
- https://doi.org/10.1097/00001756-199905140-00019