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Presence of urokinase-type plasminogen activator receptor in urine of cancer patients and its possible clinical relevance.
- Source :
-
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 1999 Jun; Vol. 79 (6), pp. 717-22. - Publication Year :
- 1999
-
Abstract
- High levels of urokinase-type plasminogen activator receptor (uPAR) are expressed in various types of cancer. Recent studies showed that cancer patients may have increased levels of soluble (s)uPAR in their serum. In the present study, we show that urine samples from healthy volunteers contain measurable amounts of suPAR. suPAR/creatinine levels from healthy controls showed only little variation over the day and were even stable during a month of continued monitoring. Importantly, urinary suPAR/creatinine levels were highly correlated with serum suPAR concentrations. Urinary suPAR levels were elevated in patients with different types of cancer. Interestingly, part of the urinary suPAR seemed to be present in a cleaved form, as has been found in tumor tissue extracts. Together with the recently established, cell migration-promoting effect of certain cleaved fragments of suPAR, the present data suggest that the measurement of urinary suPAR and/or its cleaved forms might have clinical implications.
- Subjects :
- Adult
Aged
Creatinine urine
Endometrial Neoplasms urine
Female
Humans
Infertility, Female urine
Leiomyosarcoma urine
Male
Middle Aged
Neoplasm Staging
Ovarian Neoplasms pathology
Receptors, Cell Surface analysis
Receptors, Urokinase Plasminogen Activator
Recurrence
Reference Values
Reproducibility of Results
Uterine Cervical Neoplasms urine
Uterine Prolapse urine
Biomarkers, Tumor urine
Genital Diseases, Female urine
Genital Neoplasms, Female urine
Ovarian Neoplasms urine
Receptors, Cell Surface metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0023-6837
- Volume :
- 79
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Laboratory investigation; a journal of technical methods and pathology
- Publication Type :
- Academic Journal
- Accession number :
- 10378514